Weishardt International

WEISHARDT, a relevant player in Immune health


Author: Christelle Bonnet, PhD


In 2019, the immune health supplements market size was USD16.32 billion. It is now projected to reach USD29.40 billion by 2027, with a CAGR of 7.4% during the forecast period (source:

Fortune Business Insights). COVID-19 pandemic sparked the demand for immune health supplements across the globe. This growth is attributable to the rising reconsideration of health and well-being by the masses.

Inflammation and immunity

Considering the immune health, inflammation is a vital part of the immune system’s response to infection from bacteria, viruses.., toxic compounds, or irradiation1 and acts by removing injurious stimuli and initiating the healing process2. Inflammation is therefore a defense mechanism that is essential to the immune health3. Usually, during acute inflammatory responses, cellular and molecular events and interactions efficiently minimize impending injury or infection. This process contributes to restoration of tissue homeostasis and resolution of the acute inflammation. However, uncontrolled acute inflammation may become chronic and deleterious for the organism4.

In terms of pathways, these inflammatory stimuli activate intracellular signaling pathways that activate production of inflammatory mediators such as cytokines5. The table below summarizes the cytokines and their functions (pro or anti-inflammatory).

Scientific studies show that NATICOL® downregulates pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and increases anti-inflammatory cytokines (TGF-β, IL-10).

NATICOL®, natural fish collagen peptides developed from Weishardt innovative collagen science, has preclinically demonstrated its ability to resolve inflammation – the innate reaction to preserve the immune system. Indeed, in vivo study results showed that a colonic inflammation in NATICOL®-treated DSS mice was associated with lower levels of TNF-α, IL-1β and IL-6 pro-inflammatory cytokines. The attenuated inflammation by Naticol® treatment was also supported by induced TGFβ and IL-10 anti-inflammatory cytokines secretion.


“NATICOL® Mix Immune”/ “NATICOL® Mix Immune +”, an innovative range of nutraceutical powder systems for immune Health

Due to the growing interest and demand of consumers for immune health solutions, WEISHARDT has developed a range of nutraceutical complexes under the name “NATICOL® Mix

Immune” and “NATICOL® Mix Immune +”. Formulated with NATICOL® as the main active ingredient, these powder complexes contain vitamin C (100% RDA) – which contributes to the protection of cell constituents from oxidative damage, reduction of tiredness and fatigue, normal function of the immune system (EFSA claims) – and/or minerals such as Copper (30% RDA) and Zinc (70% RDA) also contributing to the normal function of the immune health (EFSA claims). Providing established immunity solutions with vitamins and minerals but also innovative solutions with NATICOL® which showed anti-inflammatory benefits in preclinical studies (see figure above), these stable nutraceutical complexes will help you make your entrance in the Immune market segment.

WEISHARDT products are not intended to diagnose, treat, cure, or prevent any disease.



  1. Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell. 2010;140:771–776.
  2. Ferrero-Miliani L, Nielsen O, Andersen P, Girardin S. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol. 2007;147:227–235.
  1. Nathan C, Ding A. Nonresolving inflammation. Cell. 2010;140:871–882.
  2. Zhou Y, Hong Y, Huang H. Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway. Kidney and Blood Pressure Res. 2016;41:901–910.
  1. Kaminska B. MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits. BBA. 2005;1754:253–262


WEISHARDT International
81300 Graulhet
Tel: +33 5 63 42 14 41
Email: welcome@weishardt.com