Chronic pain affects today over 30% of people worldwide (1), who live with long-lasting pain that significantly diminishes their quality of life. That’s why the World Health Organization (WHO) recognizes pain as relevant topic for public health at a global level.
Pain has several and complexes mechanism, and there are many different kinds of pain, which need different treatments. As a complement to conventional treatments, nature can help address the discomforts of chronic ache. The holistic vision and the pleiotropic mechanism of action typical of natural ingredients may contribute to the need for a multidimensional approach to ache. Through the healing properties of plants and botanicals, people can find relief from these discomforts having at disposal add-on natural ingredients able to support conventional therapies for ache, for example by optimizing their intake and tolerability.
Indena has a wide products portfolio which can support ache management effectively, mainly in case of chronic pain.
Let’s mention first CRONILIEFTM, P·E·A Indena Phytosome®, an innovative health food ingredient that will be launched at Vitafoods 2025. It is based on the formulation of palmytoylethanolamide (PEA) with Indena Phytosome® technology to optimize its biological performances and health benefits.
Palmitoylethanolamide has emerged as a promising nutraceutical, being a natural lipid compound, specifically an endogenous fatty acid amide, produced in the body and known to play a key role in regulating inflammation and pain responses. Thanks to the so-called entourage effect, PEA works on multiple natural pathways positively linked to the modulation of the endocannabinoid system, influencing targets and receptors involved in the inflammatory response and in pain signalling. In CRONILIEF™, PEA natural compound gets all the advantages from Indena Phytosome® delivery system, showing optimized solubility in gastrointestinal fluids and bioabsorption, in favour of improved health benefits.
Other Indena products are effective mainly in restoring a healthy inflammatory response, which is essential for maintaining overall well-being, especially as we age or face chronic discomforts. Inflammation is a natural process that helps the body heal and protect itself, but when it becomes chronic or uncontrolled, it can lead to a variety of health issues, including joint soreness, and fatigue.
Some nutraceutical products from Indena are able to support the body’s natural ability to regulate the physiological inflammatory response and fostering long-term health.
CASPEROME®, is a full bouquet of boswellic acids featuring Indena Phytosome® technology providing a pleiotropic effect in favor of a healthy inflammatory response, proven efficacious in relieving stress and discomforts related to musculoskeletal and gut systems;
MERIVA®, is a highly bio absorbed curcumin formulated with Indena Phytosome® technology, turning ayurvedic power of curcuminoids into a science-backed ingredient supported by over 40 human studies and able to act against low chronic inflammation and supporting joint health;
MITIDOL®, is a smart ingredient combining ginger and acmella extracts, effectively joining forces to rebalance the inflammatory response in joint health thanks to a multi-target action including a proven double activity on the physiological function of human body endocannabinoid system;
QUERCEFIT®, is a quercetin-based ingredient enhancing the bioabsorption and properties of this flavanol delivered with Indena Phytosome® formulation, effective in supporting physical performance and function in sports and body fatigue-related conditions.
Moreover, an effective approach to managing chronic situations of distress can be modulating the physiological transmission of discomfort signals within the body. Indena’s portfolio includes two products able to rebalance sensory pathways, supporting the management of prolonged or recurring ache improving overall comfort.
The first is MITIDOL®, already mentioned. The second one is ACMELAINTM, an innovative acmella extract standardized in alkylamides to be combined with other functional ingredients in favor of ache-relief effect, thanks to proven modulation of natural endocannabinoid system.
Managing chronic discomforts also requires a comprehensive, 360-degree approach focused on improving the individual’s subjective experience.
Natural substances like botanicals can help since many of these natural remedies target multiple areas, such as enhancing mood, improving sleep, or helping individuals manage emotional and cognitive responses. By addressing all dimensions of the person’s well-being — including mental and emotional ones — this holistic strategy aims to create a more balanced and fulfilling life, recalibrating the body’s response, enhancing comfort, and allowing individuals to feel the balance over life challenges. In this context, Indena’s RELISSA® can be of help. It’s a standardized, non-melatonin lemon balm extract formulated with Indena Phytosome® technology and with optimized biological performance, which can improve sleep quality and ensure a beneficial action in balancing moods and contrasting tension states.
By partnering with nature through botanical solutions, we can enhance human well-being and reclaim our quality of life, also in the field of ache management.
References
- Cohen et al., “Chronic Pain: An Update on Burden, Best Practices, and New Advances”, The Lancet 397, no. 10289 (2021)
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