Bioiberica, a global life science company committed to improving the health and wellbeing of people, today announces the publication of a new peer-reviewed study supporting the skin health benefits of its hyaluronic acid (HA) matrix ingredient, Dermial® (60mg/day). In addition to confirming the ingredient’s unique ‘glow’ effect, the 12-week randomized, double-blind, placebo-controlled trial also revealed subtle differences in outcome depending on participant age. This evidence helps position Dermial® as a skin and beauty solution with both universal appeal and specific applications that speak to the needs of increasingly discerning nutricosmetic consumers.
Deepening our understanding of Dermial®
With a high concentration of hyaluronic acid (>60%), collagen and a balance of other glycosaminoglycans (GAGs) including dermatan sulfate, Dermial® is the first hyaluronic acid matrix ingredient for beauty-from-within. This debut clinical trial set out to investigate Dermial®’s effects on skin health and beauty, with initial findings presented at the Annual Meeting of the Society for Investigative Dermatology (SID) in Dallas, US in 2024. The preliminary results pointed to powerful regenerative and moisturising properties, alongside a unique ‘glow’ effect, all of which was achieved at 6 weeks with the low daily dose of 60mg per day. Now, the publication of the complete study in the peer-reviewed Dermatology and Therapy Journal confirms these effects, along with additional insights unlocking further potential for Dermial®.
The trial involved 60 healthy female participants aged 35-65 with signs of natural skin aging, who were assigned either a daily supplement of 60mg of Dermial® or a placebo. Following dermatological assessments taken at 6 and 12 weeks, researchers observed significant improvements in skin wrinkles and smoothness (at 6 weeks), as well as roughness and pH balance (at 12 weeks), compared with the placebo group.1 Participants in the Dermial® supplement group also displayed a significant increase in skin brightness and hydration, as well as decreased scaliness and skin temperature at 6 and 12 weeks. The study also confirms the high levels of participant satisfaction, with 69% of those in the Dermial® group stating they were very satisfied or satisfied, and none reporting being dissatisfied or very dissatisfied.
Beauty benefits at every age
Beyond confirming the ingredient’s holistic beauty benefits, a sub-analysis of the study’s results suggests that Dermial® could also offer different skin-supporting effects depending on a user’s age. Participants over 55 years old showed significant improvements across many skin barrier function parameters, including brightness/glow, hydration, deformability, smoothness, roughness, scaliness and temperature Notably, pH balance was also maintained in this older group, unlike the placebo group. These findings suggest Dermial® can address age-related skin concerns, such as the appearance of wrinkles and fine lines, dryness, dullness, roughness, and loss of firmness, by improving the skin’s barrier function and microtopography.
“We are so excited to share the full details of this ground-breaking debut clinical trial, demonstrating the incredible potential Dermial® holds for nutraceutical innovation,” comments Daniel Martínez-Puig, Head of R&D Human and Animal Health at Bioiberica and one of the study’s authors. “While overall improvements were less pronounced in volunteers younger than 55 years, they nevertheless experienced benefits in hydration, brightness, and smoothness. These results point to the versatility of Dermial® as a skin health supplement, able to meet consumers where they are in their skin health journey, regardless of age.”
The full study results can be read at: https://link.springer.com/article/10.1007/s13555-025-01447-6?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20250611&utm_content=10.1007%2Fs13555-025-01447-6#citeas
For more information about Bioiberica’s human health portfolio, please visit: Bioiberica’s Branded Ingredients.
These statements have not been evaluated by competent food authorities. The product is not intended to diagnose, treat, cure, or prevent any disease. This information is only for business-to-business use and not meant to be addressed to final consumers.
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