New Research (December 2023) featuring Pomella®, a patented pomegranate extract, was evaluated for its impact on gut microbiome, short chain fatty acids (SCFA) and mitochondrial health.
A four-week, double-blind, placebo-controlled, randomized clinical trial1 evaluated 250mg/day of Pomella® in healthy adults 25-55yrs (n=18, predominantly women) for beneficial effects on the gut microbiome, circulating short-chain fatty acids and gut-microbial derived ellagitannin metabolites, namely urolithins, using whole genome sequencing for gut microbial analysis.
The results revealed that gut functional analyses are consistent with circulating short-chain fatty acids (SCFAs), reinforcing the idea that Pomella® supplementation improves SCFA levels by influencing the gut microbiome. These results imply that consuming Pomella® pomegranate extract promotes a healthier gut and improves gut-body communication.1
Expanding on these findings, researchers highlighted significant changes in short-chain fatty acids (SCFAs) pre and post Pomella® extract supplementation. They observed a 162% rise in propionate levels (p = 0.02) and a 38% increase in acetate levels (p = 0.12) following Pomella® supplementation.1
Moreover, the study noted an increase in certain species such as Coprococcus eutectus, Roseburia faecis, Roseburia inulinivorans, Ruminococcus bicirculans, Ruminococcus calidus, Faecalibacterium prausnitzii, Methanobrevibacter smithii, and Collinsella aerofaciens within the Pomella® group. This suggests that ellagitannins from pomegranate may trigger changes in these bacteria, potentially influencing overall health by affecting short-chain fatty acids, secondary metabolites, and the synthesis of urolithin A.1
“We are thrilled to have this new publication in support of Pomella®,” explains Kristen Marshall, digital marketing manager with Verdure Sciences®. “The support for the gut microbiome, short chain fatty acids, metabolic health, mitochondrial and cellular support are all areas we have seen previous data support. This study helps bolster an already interesting story—making it much more compelling now. Tremendous interest continues to build for gut and digestive health, skin support and beauty from within as well as specific gut and skin microbiota and we are honoured that Pomella® is so well poised to tackle this category’s needs”.
“It is interesting to see how science around Pomella® over the last ten years have shifted focus from demonstrating important results on the role of Pomella® as a bioavailable, powerful antioxidant with several benefits to human health to new exciting findings on gut microbiome support and the link with skin health and overall health” Added Teresita Ruda’, Head of Brands and Marketing at LEHVOSS Nutrition. “Pomella® is certainly a game-changer, and we look forward to seeing new exciting data in the near future”.
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